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Acute membrane repair for deadly degenerative diseases

About us

Our company

Amporin Pharmaceuticals is an emerging Swiss biotech company focused on the development of a breakthrough new class of small molecule membrane-protecting therapies for the treatment of neurodegenerative diseases – including ALS, Alzheimer's, Parkinson's, and many other degenerative diseases associated with protein misfolding and aggregation.
Our vision is to transform the treatment of these diseases by specifically protecting vital cellular membranes against the toxic pore formation of soluble oligomers that are now believed to cause all these diseases.
Our team is led by experienced drug discovery and development executives, neurologists, physicians and scientists, who are deeply committed to our unique technology, asset platforms and scientific approach, as well as each and every patient we aim to help.
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Our therapeutic focus

At least 50 deadly ageing-related diseases, including Alzheimer's, diabetes, Parkinson's, and many rare degenerative diseases, are now associated with abnormal protein misfolding and aggregation (see background). Our initial focus is on Parkinson's, Alzheimer's disease and Amyotrophic Lateral Sclerosis.
In every one of these diseases, a specific protein or peptide aggregates in a particular part of the brain or body to form toxic soluble oligomers or amyloid pores that puncture holes in cell membranes, causing uncontrolled calcium influx, aberrant cell signalling, loss of homeostasis, oxidative stress, inflammation, and progressive cell death and degeneration.
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Our unique approach

All these diseases have been associated with the misfolding and aggregation of specific proteins or peptides to form oligomeres and insoluble 'amyloid fibers'. For many years the biopharma industry has focused on developing antibodies against these fibres and oligomeres However, this approach has completely failed as the insoluble fibers are not pathogenic.
Recent research has revealed that these disease-associated peptides also aggregate to form 'amyloid pores' within membranes of cells and organelles. These pores lead to dysfunction of cells and ultimately trigger cell death and degeneration .
Based on this emerging science, Amporin Pharmaceuticals was established to develop a new class of small molecule drugs that specifically target these amyloid pores, as potential disease-modifying treatments for all protein misfolding diseases.
While the biopharma industry has failed by targeting insoluble amyloid fibers, we specifically target amyloid pores because these are now known to cause dell death and degeneration by puncturing holes in cell membranes.

Our solution

We are developing three new classes of orally available, brain-penetrating drugs that specifically target amyloid pores within cell membranes:
  • Amporbans – our First-in-Class amyloid pore-blocking agents effectively block amyloid pores like a plug, so that they are no longer permeable to calcium and other ions.
  • Amporins – our First-in-Class amyloid pore inhibitors specifically inhibit and reverse the formation of amyloid pores within cell membranes, effectively dissolving them from the membrane like target-specific detergents.
  • Amportacs – our First-in-Class amyloid pore-targeting chimeras actively promote the targeted ubiquitination and degradation of amyloid pores by the proteasome within the cell.
We are now building a strong and steady pipeline of drug candidates, which have the potential to become the first and most effective disease-modifying treatments for all protein misfolding diseases.
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