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Membrane-protecting therapies for neurodegenerative diseases

Our therapy areas

Protein misfolding diseases

Disease
Associated protein/peptide
Symptomatic treatments
Disease-modifying treatments
Parkinson's disease (PD)
α-Synuclein (αSyn)
Levodopa with carbidopa, COMT inhibitors, dopamine agonists, MAO inhibitors, melatonin, clonazepam, acetylcholinesterase inhibitors
None
Alzheimer's disease (AD) Hereditary cerebral haemorrhage with amyloidosis (HCHWA) Cerebral amyloid angiopathy (CAA) Inclusion body myositis (IBM) Retinal degeneration (glaucoma) Macular degeneration (AMD)
β-amyloid peptide (Aβ) Tau protein (Tau)
Acetylcholinesterase inhibitors (tacrine, rivastigmine, galantamine donepezil), memantine
None - Lecanemab is approved by FDA
Amyotrophic lateral sclerosis (ALS)



Alzheimer's disease (AD) Hereditary cerebral haemorrhage with amyloidosis (HCHWA) Cerebral amyloid angiopathy (CAA) Inclusion body myositis (IBM) Retinal degeneration (glaucoma) Macular degeneration (AMD)
β-amyloid peptide (Aβ) Tau protein (Tau)
Acetylcholinesterase inhibitors (tacrine, rivastigmine, galantamine donepezil), memantine
None - Lecanemab is approved by FDA
Amyotrophic lateral sclerosis (ALS)
TAR DNA-binding protein 43 (TDP-43), Fused in sarcoma (FUS), Ubiquilin-2 (UBQLN2), Superoxide dismutase (SOD1)
Riluzole, edaravone, selective serotonin reuptake inhibitors (SSRIs), cholinesterase inhibitors, antipsychotics
None
Huntington's disease (HD) Other CAG repeat disorders: Spinal and bulbar muscular atrophy Spinocerebellar ataxia (SCA1, etc.) Dentatorubropallidoluysian atrophy
Huntingtin (HTT) Other polyglutamine-containing proteins: Androgen receptor (AR), Ataxin-1, 2, 3, Atrophin-1 (ATN1)
Tetrabenazine, benzodiazepines, valproic acid, antipsychotics
None
Other synucleinopathies: Parkinson's disease dementia (PDD)Dementia with Lewy bodies (DLB)Multiple system atrophy (MSA)REM sleep behavior disorder (RBD)



Other β-amyloid pathologies: Hereditary cerebral haemorrhage with amyloidosis (HCHWA) Cerebral amyloid angiopathy (CAA) Inclusion body myositis (IBM) Retinal degeneration (glaucoma) Macular degeneration (AMD)
β-amyloid peptide (Aβ)
Antihypertensives, corticosteroids, anticonvulsants
None
Other tauopathies: Chron. traum. encephalopathy (CTE)Progressive supranuclear palsy (PSP) Corticobasal degeneration (CBD) Argyrophilic grain disease (AGD)
Tau protein (Tau)
Selective serotonin reuptake inhibitors (SSRIs), antipsychotics, acetylcholinesterase inhibitors, levodopa, amantadine, ropinirole, clonazepam, memantine
None
Frontotemporal dementia (FTD) Other forms of frontotemporal lobar degeneration (FTLD): Semantic dementia (SD)
Tau protein (Tau), TAR DNA-binding protein (TDP-43), Fused in sarcoma protein (FUS)
Selective serotonin reuptake inhibitors (SSRIs), antipsychotics, acetylcholinesterase inhibitors
None
Type II diabetes (T2D)
Islet amyloid polypeptide (IAPP)
Metformin, thiazolidinediones, sulfonylureas, SGLT2 inhibitors, insulin and insulin analogs
None
Creutzfeldt-Jacob disease (CJD)Other prion diseases: Gerstmann–Sträussler–Scheinker syndrome (GSS); Fatal familial insomnia (FFI)
Prion protein (PrP)
None
None
Senile systemic amyloidosis (SSA) Other transthyretin pathologies: Hered. transthyretin amyloidosis Fam. amyloid polyneuropathy (FAP) Fam. amyloid cardiomyopathy (FAC)
Transthyretin (TTR)
Tafamidis (EU only), diflunisal
Patisiran (siRNA therapy) Inotersen (antisense therapy)
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